Cancer recurrence after surgery determines the prognosis of patients. An avoidable cause of recurrence is the remaining positive margin after surgery, meaning that invisible tissue containing cancer cells is still present in the organs after the tumour resection. If margins come positive in the histopathological analysis, patients need strict follow-up after surgery for years, or even undergo aggressive interventions such as radiotherapy and chemotherapy, second surgeries… and some eventually die.

These severe outcomes have also a high cost in the quality of life and expectations in patients and their families resulting in an unbearable burden emotionally and economically.